Tissue engineering technologies: bioartificial pancreas for regenerative medicine in diabetes mellitus

Anna S. Ponomareva

Biomedical Technology and Tissue Engineering Department, Shumakov National Medical Research Center of Transplantology and Artificial Organs, Russia

Most tissue-engineered constructs developed in the world include specific cells and scaffolds that provide them the necessary conditions for long-term viability and functional activity. Developing methods for obtaining biocompatible scaffolds capable of providing mechanical support and an appropriate microenvironment for cells in vitro and in vivo represents a key challenge in tissue engineering. Tissue-specific scaffolds, fabricated through the removal of cellular elements and their fragments from the donor organ tissues while maximally preserving the extracellular matrix's structure and composition, are of particular interest. This report is dedicated to the systematization of own and literary data concerning the development and application of extracellular matrix biomimetics for the creation of pancreatic tissue-engineered constructs aimed at correcting type I diabetes mellitus.